Novel Insights into the Cardio-Protective Effects of FGF21 in Lean and Obese Rat Hearts

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Novel Insights into the Cardio-Protective Effects of FGF21 in Lean and Obese Rat Hearts

AIMS Fibroblast growth factor 21 (FGF21) is a hepatic metabolic regulator with pleotropic actions. Its plasma concentrations are increased in obesity and diabetes; states associated with an increased incidence of cardiovascular disease. We therefore investigated the direct effect of FGF21 on cardio-protection in obese and lean hearts in response to ischemia. METHODS AND RESULTS FGF21, FGF21-r...

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ژورنال

عنوان ژورنال: PLoS ONE

سال: 2014

ISSN: 1932-6203

DOI: 10.1371/journal.pone.0087102